Descriptio

Hydrochlorothiazide (HCTZ), pharmacum ore activum diureticum classis thiazide, vetat TGF- transformans.β/Smad iter significans. Hydrochlorothiazide remissos effectus vascularis directos per foramen canalis potassii calcii actuati (KCA) habet. Hydrochlorothiazide munus cardiacum ampliat, fibrosim minuit et effectum antihypertensivum habet.

Background

Hydrochlorothiazide medicamentum diureticum classis thiazide est.

in Vitro

Hydrochlorothiazide ad thiazide diureticorum genus pertinet. Volumen sanguinis reducit a renibus ad reducendum sodium (Na) reabsorptionem in distali tubulis convolutis. Maior situs actionis in nephrone apparet in electroneutrali Na+-Cl co-portatori, certando de situ chloridi in transportatore. Deminuto Na onerariis in tubulis convolutis distali, hydrochlorothiazide natriuresim et damnum aquae concomitantis inducit. Thiazides reabsorptionem calcii auget in hoc segmento modo ad transportandum sodium finitum. Accedit ab aliis mechanismis Hydrochlorothiazide creditur resistentia periphericis vascularium inferiori.

Hydrochlorothiazide (HCTZ; viva voce bygavagum; 12.5 mg/kg/d; 8 hebdomades) munus cardiacum emendavit, cardiacam fibrosis interstitialem redactam et fractionem voluminis collageni, expressionem AT1, TGF- decrevit.β et Smad2 in fibris cardiacis in muribus adultis Sprague Dawley. Praeterea hydrochlorothiazide plasma angiotensin II et aldosterones gradus minuit. Praeterea hydrochlorothiazide inducitur angiotensin II-TGF-.β1 et Smad2 significatio interdum in rat fibroblastis ventricularis neonatales.

Chemical structure