Canagliflozin

Description:

API Nomen Indicium Specification US DMF EU DMF CEP
Canagliflozin Typus 2 diabete In-Domus    


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Background

Canagliflozin nova, potens, et valde selectiva sodium glucosi co-portatoris (SGLT) 2 inhibitoris [1] est.Probatum est Canagliflozin excretionem glucosi urinam augere, reducendo limen glucosi renum et decrescendo glucose eliquatum re- effusio [2].

Canagliflozin ostensa est inhibere capita Na+mediatae 14C-AMG in CHO-hSGLT2, CHO rat GLT2 et CHO-mus GLT2 cum valoribus IC50 4.4, 3.7 et 2.0 nM, respective [1].

Canagliflozin relatum est ad minuendum sanguinem Glucosum (BG) gradus dosis dependentis in utroque db/db Mures et Zucker diabeticum pingue (ZDF) Rats.Accedit, canagliflozin probavit deminuere rationem permutationis respiratorii, et pondus corporis in DIO mures et mures ZDF [1].

Canagliflozin viva voce accipi potest [1].

Notae:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polydori D, Mores K, Demarest K. Effectus canagliflozin in limine renum pro glucose, glycemia, et pondere corporis in exemplaribus animalis normalibus et diabeticis.PLoS PRIMUM.2012; 7(2): e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), agentis oralis novi generis 2 diabete.P T. 2013 Nov

Product Citation

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al."Diversae resolutiones technicae ad administrationem spectris imbricati: applicatio ad determinationem medicamentorum hypoglycemicorum novorum co-formatorum in compositione dosis pharmaceuticae".Spectrochimica Acta Pars A: Molecular and Biomolecular Spectroscopy Available online 20 June 2018

Chemical structure

Canagliflozin

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

QUALITY MANAGEMENT

Quality management1

Rogatio18Qualitas Constantia Aestimatio inceptis quae probaverunt4, et6incepta approbantes.

Quality management2

Provectus qualitas internationalis administrandi ratio solidum fundamentum venditio posuit.

Quality management3

Qualitas vigilantia percurrit totum vitae cyclum producti, ut qualitatem et therapeuticum effectum curet.

Quality management4

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SOCIUS

Cooperatio internationalis
International cooperation
Cooperatio domestica
Domestic cooperation

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