Pitavastatin Calcium
| 匹伐 他 汀钙 | Pitavastatin | 147526-32-7 | In-Domus |
| PI-5 | 3800-06-4 | In-Domus | |
| PI-6 | 145516-11-4 | In-Domus | |
| PI-7 | 121660-11-5 | In-Domus |
Descriptio
Pitavastatin calcium (hemicalcium NK-104) hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor est potentior.Pitavastatin Calcium (NK-104 hemicalcium) vetat synthesin cholesterol ab acetico acetico cum IC50 ex 5.8 nM in cellulis HepG2.Pitavastatin Calcium est hepatocytum humilis densitatis lipoprotein-cholesterol (LDL-C) receptor efficientis inducentis.Cancri anti- actio.
Background
Pitavastatin Calcium inhibitor competitive est enzyme HMGCR (HMG-CoA reductase) reductionem in synthesi cholesteroli LDL.Studia alterna ostendunt pitavastatin productionem oxygenii supprimi posse in cellulis endothelialibus, inhibitione oxidasi NADPH.Praeterea pitavastatin expressionem eNOS mRNA minuit dum responsio dependens NO augens ab acetylcholino ac calcii ionophore excitata, A23187.Praeterea, pitavastatin impedit regulam conductionis calcii-canales potassium effectae per gradus cholesteroli in cellulis demisso.
Repono
4°C, defendat a lumine
*In solvendo: -80°c, menses VI;-20°C, 1 mensis (protegat a luce)
Chemical structure
Related Biological Data
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