Pitavastatin Calcium
| 匹伐他汀钙 | Pitavastatin | 147526-32-7 | In-Domus |
| PI-5 | 3800-06-4 | In-Domus | |
| PI-6 | 145516-11-4 | In-Domus | |
| PI-7 | 121660-11-5 | In-Domus |
Descriptio
Pitavastatin Calcium (hemicalcium NK-104) hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor est potentior. Pitavastatin Calcium (NK-104 hemicalcium) vetat synthesin cholesterolum ab acetico acido cum IC50 ex 5.8 nM in cellulis HepG2. Pitavastatin Calcium est hepatocytum humilis densitatis lipoprotein-cholesterolum (LDL-C) efficientem receptaculum inducentis. Cancri anti- actio.
Background
Pitavastatin Calcium inhibitor competitive est enzyme HMGCR (HMG-CoA reductase) in reductione synthesis cholesteroli LDL. Studia alterna ostendunt pitavastatin productionem oxygenii posse supprimere in cellulis endothelialibus, inhibitione oxidasi NADPH. Praeterea pitavastatin expressionem eNOS mRNA minuit dum responsio dependens NO augens ab acetylcholino ac calcii ionophore excitata, A23187. Praeterea pitavastatin inhibet regulam conductionis calcii-canales potassium effectae per gradus cholesteroli in cellulis demisso.
Repono
4°C, protegat a lumine
*In solvendo: -80°c, menses VI; -20°C, 1 mensis (protegat a luce)
Chemical structure
Related Biological Data
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