Sacubitril Hemicalcium
| 沙库 比曲 半 钙 盐 | Sacubitril Hemicalcium | 1369773-39-6 | In-Domus |
| 沙库 比曲 钠盐 | 149690-05-1 | In-Domus | |
| LCZ-4 | 1426129-50-1 | In-Domus | |
| LCZ-7 | 1012341-48-8 | In-Domus | |
| LCZ-8 | 1012341-50-2 | In-Domus | |
| LCZ-9 | 149690-12-0 | In-Domus |
Background
AHU-377 sal hemicalcium est hemicalcium salis forma AHU-377.Inhibitor neprilysin cum IC50 valore 5 nM [1] est.
AHU-377 et angiotensin II AT1 receptor antagonistam valsartanam componunt LCZ696 in ratione molari 1, 1;LCZ696 receptor angiotensin neprilysin inhibitor est.Potest reducere sanguinem pressura et novum medicamentum ad cordis defectum curationem.AHU-377 pro-medicamentum est, ab enzymatica ethyl niensis in formam activam converti potest LBQ657.Ferunt AHU-377 (30 et 100 mg/kg, PO) effectum antihypertensivum causare posse in modo dosi dependens mures DAHI-SS.Sed in DOCA-sal hypertensiva mures infirma reductionem ostendit [2, 3].
Notae:
[1] Ksander GM, Ghai RD, Jesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Acidum Dicarboxylicum dipeptidum neutrum endopeptidase inhibitores.J Med Chem.1995 May 12;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Partes potentiales valsartan + AHU377 (LCZ696) in curatione cordis defectio.Expert Opin Investig Medicamenta.2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecilia Yu, Cheruvu Madhavi et al.Efficacia comparativa de AHU-377, neprilysin inhibitoris potentis, in duobus exemplaribus hypertensionis tomi-dependens.BMC Pharmacology 2011, 11 (Suppl 1): P33.
Chemical structure
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