Vericiguat
Vericiguat estpyrazolopyridinehoc est5-fluoro-1H-pyrazolo[3,4-b]pyridinein quo amino hydrogenii in positione 1 substituti sunt per 2-fluorobenzyl coetus ethydrogeniiin positione 3 substitutus est per 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. Solutum estguanylatecyclasus excitator qui adhibetur ad defectum cordis curatio chronica. Partes habet quasi solutumguanylatecyclasus activus, agens vasodilator et agens antihypertensivum. Est anaminopyrimidine, apyrazolopyridinecarbamate ester et mixtum organofluorinum.
Vericiguat quaesitum est in iudiciis clinicis NCT02861534 (A Study of Vericiguat in Participantibus Cum Cordis defectione Reductio Fraction (HFrEF) (MK-1242-001)).
Vericiguat SolubleGuanylateCyclase Stimulator. Mechanismus actionis vericiguati est ut aGuanylateCyclase Stimulator.
Vericiguat medicamentum adhibitum est ad defectum cordis regendum et tractandum cum fractione eiectione reducta (HFrEF). Utile est inveterata ingravescentem cordis defectum, nuper cordis defectum compensantis. Vericiguat salutem non prorogat sed restaurationem impedit. Haec actio indicia, mechanismum actionis, dosis ac modum administrationis delineat per interprofessionales equos, adversas effectus, contraindicationes et plures probationes ad probationes utilitatis medicamentorum in HFrEF sustinendas.
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