Agomelatine

Description:

API Nomen Indicium Specification US DMF EU DMF CEP
Agomelatine Depressione In-Domus    


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Background

Agomelatina est agonista receptorum melatonini et antagonista serotonin 5-HT2C receptoris cum valore Ki 0.062nM et 0.268nM et IC50 valoris 0.27µM, respective pro MT1, MT2 et 5-HT2C [1].

Agomelatina unicum antidepressum est et ad curationem inordinationis depressivae maioris (MDD).Agomelatina selectiva contra 5-HT2C.Affinitas ignobiles ostendit homini 5-HT2A et 5-HT1A.Receptores melatonini, agomelatinae similes affinitates cum MT1 et MT2 coniunctis ostendit cum valore Ki 0.09nM et 0.263nM, respective.In studiis vivis, agomelatinae incrementa dopaminis et gradus noradrenalini causant per obstaculum inhibitoriae initus 5-HT2C.Praeterea administratio agomelatinae resistit accentus minui inductus in consumptionem sucrosae in rat exemplar depressionis.Praeter haec, agomelatina efficaciam in rodenti exemplari sollicitudinis levatam exercet [I].

Notae:
[1] Zupancic M, Guilleminault C. Agomelatine.CNS medicinae MMVI, XX (12): 981-992.

Chemical structure

Agomelatine

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

QUALITY MANAGEMENT

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SOCIUS

Cooperatio internationalis
International cooperation
Cooperatio domestica
Domestic cooperation

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