Atorvastatin Calcium

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API Nomen Indicium Specification US DMF EU DMF CEP
Atorvastatin Calcium Hypercholesterolemia In-Domus/CEP 29057 CEP 2015-034


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Background

Atorvastatin Calcium potens inhibitor HMG-CoA reductase cum valore IC50 150 nM [1] est.
HMG-CoA reductase est clavis enzyme viae mevalonatae quae cholesterolum producit.HMG-CoA enzyme in rate limitans est et magni momenti est ad gradus cholesteroli sanguinis deducendos.HMG-CoA reductase in reticulo endoplasmico sita et octo ditiones transmembranas continet.Inhibitores reductase HMG-CoA LDL (demissam densitatem lipoprotein) receptores expressionem in hepate inducere possunt.Ducit augere gradus catabolismi plasmatis LDL et demittere intentionem plasmatis cholesteroli quod est magni momenti determinatio atherosclerosi.HMG-CoA reductase magni ponderis partes agit in synthesi cholesterol.HMG-CoA unicum signum est medicinae cholesterol-minae.HMG-CoA reductase enzyme magni momenti est ad evolutionem.Actio reductasi HMG-CoA ad vitia migrationis cellae germinis refertur.Inhibitio suae activitatis potest ducere ad haemorrhagia intracerebralem.
Atorvastatin inhibitor reductasi HMG-CoA cum IC50 valore 154 nM est.Valet in quibusdam dyslipidemias et hypercholesterolemia tractando[1].Curatio Atorvastatin ad 40 mg medicamentum totalis cholesterolum 40% post 40 dies decrescit.[1]Etiam coronarios vel plagas aegros tractare cum gradibus cholesteroli normalibus.Atorvastatin etiam diminuit densitatem lipoprotein humilis apheresis in aegris inducendo expressionem LDL-receptorum.
Metabolized est pluribus metabolitis quae momenti sunt ad effectum actionum therapeuticorum ab CYP3A4 (cytochrome P450 3A4).
Notae:
[1].van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Longa vox efficacia et salus atorvastatin in curatione generis severi III et dyslipidaemia coniuncta.Cor 2002, 88 (3): 234-238.
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Praeventionis coronariorum et ictuum eventuum cum atorvastatin in aegris hypertensivis qui mediocris vel inferiores habent. - Mediocris concentrationis cholesteroli, apud Cardiac Proventus Anglo-Scandinavianus Trial--Lipidus Brachii deminutus (ASCOT-LLA): multicentre incerti iudicii moderati.Lancet 2003, 361(9364):1149-1158.
[3].Lennernas H: Fusce pharmacokinetics of atorvastatin.Clin Pharmacokinet 2003, 42 (13):1141-1160.

Chemical structure

Atorvastatin-Calcium

CERTIFICATE

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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