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Tofacitnib Citrate

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API Nomen	Indicium	Specification	US DMF	EU DMF	CEP
Tofacitnib Citrate	Rheumatoid arthritis	In-Domus

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Background

Tofacitinib citratum, etiam ut CP-690550 citratum, est potens inhibitor iani kinasi 3 (JAK3), cellam hematopoeticam restrictam tyrosine kinase implicatam in signo translationis lymphocytae superstitialis, multiplicationis, differentiationis et apoptosis.Inhibitio JAK3 specifica est cum selectivity 1000-duplici prae aliis kinasibus familiae non-JAK.Praeter inhibendo JAKS (IC50 = 1 nM), tofacitinib citricis etiam vetat janus kinasus 2 (JAK2) et janus kinasus 1 (JAK1) cum 20- et 100-plica minus in potentia respective.Attamen in recenti studio, affinitates ligaturae (Ki) de tofacitinib citratis versus JAK1, JAK2, et JAK3 relati sunt 1.6 nM, 21.7 nM, et 6.5 nM respective.

Reference

Lalitha Vijayakrishnan, R. Venkataramanan et Palak Gulati.De inflammatione cum iano kinase inhibitore CP-690,550.Trends in pharmacological Sciences 2011: 32 (1);25-34

Product Citation

1. Panagi I, Jennings E, et al."Salmonella Effector SteE Mammalian Serinam/ Threoninam Kinase GSK3 vertit in Kinase Tyrosinam ad Macrophage Polarizationem Direct."Cellula Hostiae Microbe.2020, 27 (1): 41-53.e6.PMID:31862381
2. McInnes IB, Byers NL, et al."Comparatio baricitinib, upadacitinib, et tofacitinib ordinatio mediata cytokini significat in leukocyte subpopulationes humanas."Arthritis Res Ther.MMXIX Aug 2, 21 (1):183.PMID:31375130
3. Liu S, Verma M, et al."Resistentia steroidis airway type 2 cellulis lymphaticis innatis ab aegrotis gravi asthmate: Partes lymphopoietin stromalis thymici."J Allergy Clin Immunol.2018 Ian;141(1):257-268.e6.PMID:28433687
Zheng, Lufeng, et al." 3′ UTR pseudogenie CYP4Z2P tumorem angiogenesis in cancro pectori promovet, ut cerNA pro CYP4Z1 agendo."Investigationes et curationes cancer pectoris (2015): 1-14.PMID:25701119

Descriptio

Tofacitinib citratum viva voce promptum est inhibitor JAK1/2/3 cum IC50s de 1, 20, et 112 nm, respective.Tofacitinib citratum habet actiones antibacterial, antifungales et antivirales.

Repono

4°C, custodi a lumine

*In solvendo: -80°C, menses 6;-20 ° F, mensis I (protegat a lumine)